High-Density Lipoproteins and Endothelial Function
نویسندگان
چکیده
منابع مشابه
High-density lipoproteins and endothelial function.
Elevated plasma levels of HDL cholesterol or apolipoprotein A-I, the major protein moiety of HDL particles, are protective against coronary artery disease. HDL particles remove cholesterol from peripheral cells and transfer it to the liver for bile acid synthesis. The interaction between lipoproteins is not mediated through simple contact between 2 phospholipid membranes but involves specific p...
متن کاملHigh-Density Lipoproteins, Endothelial Function, and Mendelian Randomization.
Although plasma high-density lipoprotein (HDL) cholesterol levels correlate inversely with the incidence of cardiovascular disease, the causative nature of this relationship has been called into question by Mendelian randomization studies and several failed clinical trials involving HDL-raising drugs. Studies in humans have indicated that the macrophage cholesterol efflux capacity of HDL is a s...
متن کاملEndothelial protection by high-density lipoproteins: from bench to bedside.
There are several potential mechanisms by which HDLs protect against the development of vascular disease. One relates to the unique ability of these lipoproteins to remove cholesterol from the arterial wall. Another is the ability of HDL to prevent and eventually correct endothelial dysfunction, a key variable in the pathogenesis of atherosclerosis and its complications. HDLs help maintain endo...
متن کاملHigh-density lipoproteins reduce endothelial-to-mesenchymal transition.
OBJECTIVE Endothelial-to-mesenchymal transition is an inflammation-induced process by which endothelial cells can transdifferentiate into fibroblasts. Based on the endothelial-protective and antifibrotic effects of high-density lipoproteins (HDL), we aimed to investigate whether HDL can reduce endothelial-to-mesenchymal transition. APPROACH AND RESULTS Therefore, human aortic endothelial cell...
متن کاملSphingomyelin in High-Density Lipoproteins: Structural Role and Biological Function
High-density lipoprotein (HDL) levels are an inverse risk factor for cardiovascular diseases, and sphingomyelin (SM) is the second most abundant phospholipid component and the major sphingolipid in HDL. Considering the marked presence of SM, the present review has focused on the current knowledge about this phospholipid by addressing its variable distribution among HDL lipoparticles, how they a...
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ژورنال
عنوان ژورنال: Circulation
سال: 2001
ISSN: 0009-7322,1524-4539
DOI: 10.1161/hc3901.096667